- Obesity and Metabolism
- Metabolic and Cardiovascular Implications of a Metabolically Healthy Obesity Phenotype
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Mi Hae Seo, Eun-Jung Rhee
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Endocrinol Metab. 2014;29(4):427-434. Published online December 29, 2014
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DOI: https://doi.org/10.3803/EnM.2014.29.4.427
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Abstract
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Metabolically healthy obesity (MHO) is a new concept in which an individual may exhibit an obese phenotype in the absence of any metabolic abnormalities. There are a number of definitions of MHO that utilize a variety of components. The findings of clinical and basic studies indicate that subjects with MHO do not exhibit an increased mortality, an increased risk of cardiovascular disease, or an increased risk of type 2 diabetes mellitus, as compared to normal-weight controls. Although these findings imply that metabolic health is a more important factor than obesity, several studies have shown that subjects with MHO have a similar risk of metabolic or cardiovascular diseases as those with metabolically unhealthy obesity. Thus, there is still debate regarding not only the implications of the MHO phenotype but its very existence. Accordingly, future studies should focus on developing a unified definition of MHO and distinguishing subjects who will be at a high risk for metabolic and cardiovascular diseases.
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- Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study
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Ennio Avolio, Paola Gualtieri , Lorenzo Romano, Claudio Pecorella, Simona Ferraro, Giuseppe Palma, Laura Di Renzo, Antonino De Lorenzo Current Medicinal Chemistry.2020; 27(2): 216. CrossRef - Different Patterns of Left Ventricular Hypertrophy in Metabolically Healthy and Insulin-Resistant Obese Subjects
Angela Sciacqua, Antonio Cimellaro, Luana Mancuso, Sofia Miceli, Velia Cassano, Maria Perticone, Teresa V. Fiorentino, Francesco Andreozzi, Elena Succurro, Giorgio Sesti, Francesco Perticone Nutrients.2020; 12(2): 412. CrossRef - Phenotypic classification and biochemical profile of obesity for cardiovascular prevention
Marco A. Perrone, Jagadish Babu Dasari, Alfredo Intorcia, Paola Gualtieri, Massimo Marche, Marco Di Luozzo, Giuseppe Merra, Sergio Bernardini, Francesco Romeo, Domenico Sergi Gazzetta Medica Italiana Archivio per le Scienze Mediche.2020;[Epub] CrossRef - Are young Iranian women with metabolically healthy obesity at increased risk of CVD incidence?
Seyed Ahmad Hosseini, Vahideh Aghamohammadi, Damoon Ashtary-Larky, Meysam Alipour, Matin Ghanavati, Nasrin Lamuchi-Deli Jornal Vascular Brasileiro.2020;[Epub] CrossRef - Metabolically healthy obese phenotype and risk of cardiovascular disease: Results from the China Health and Retirement Longitudinal Study
Haibin Li, Dian He, Deqiang Zheng, Endawoke Amsalu, Anxin Wang, Lixin Tao, Jin Guo, Xia Li, Wei Wang, Xiuhua Guo Archives of Gerontology and Geriatrics.2019; 82: 1. CrossRef - Metabolic phenotypes of obese, overweight, and normal weight individuals and risk of chronic kidney disease: a systematic review and meta-analysis
Shahab Alizadeh, Hamed Esmaeili, Mohammad Alizadeh, Elnaz Daneshzad, Loghman Sharifi, Hossein Radfar, Mohammad Kazem Radaei Archives of Endocrinology and Metabolism.2019;[Epub] CrossRef - Metabolic health is more closely associated with decrease in lung function than obesity
Hea Yon Lee, Hae Kyung Yang, Ho Jin Song, Hee Jae Chang, Ji Young Kang, Sang Haak Lee, Solji Han, Young Kyoon Kim, Anna Halama PLOS ONE.2019; 14(1): e0209575. CrossRef - Relations of major dietary patterns and metabolically unhealthy overweight/obesity phenotypes among Iranian women
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A. Rodríguez‐Campello, J. Jiménez‐Conde, Á. Ois, E. Cuadrado‐Godia, E. Giralt‐Steinhauer, R. M. Vivanco, C. Soriano‐Tárraga, I. Subirana, D. Muñoz, A. Gómez‐González, A. Puig‐Pijoan, J. Roquer European Journal of Neurology.2017; 24(2): 397. CrossRef - Letter: Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension (Endocrinol Metab 2017;32:221-9, Mohsen Janghorbani et al.)
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Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Jung Eun Jang, Jenie Yoonoo Hwang, Eun Hee Kim, Woo Je Lee, Joong-Yeol Park, Hong-Kyu Kim, Clemens Fürnsinn PLOS ONE.2017; 12(6): e0179635. CrossRef - Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation
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Sima Hashemipour, Neda Esmailzadehha, Mahdieh Mohammadzadeh, Amir Ziaee Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2016; 21(3): 419. CrossRef - Obesity and Cancer—Opportunities to Break the Link
Daniel F. Argolo, Clifford A. Hudis, Neil M. Iyengar Current Breast Cancer Reports.2016; 8(1): 22. CrossRef - Circadian Rhythms of Carbohydrate Metabolism in Women with Different Types of Obesity
B. B. Pinkhasov, V. G. Selyatinskaya, E. L. Astrakhantseva, E. V. Anufrienko Bulletin of Experimental Biology and Medicine.2016; 161(3): 323. CrossRef - Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals
Xiang Gao, Weidong Zhang, Yongbo Wang, Pardis Pedram, Farrell Cahill, Guangju Zhai, Edward Randell, Wayne Gulliver, Guang Sun Nutrition & Metabolism.2016;[Epub] CrossRef - Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study
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Daniel F. Argolo, Neil M. Iyengar, Clifford A. Hudis Indian Journal of Surgical Oncology.2015; 6(4): 390. CrossRef - Vasodilator responses and endothelin-dependent vasoconstriction in metabolically healthy obesity and the metabolic syndrome
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- Obesity and Metabolism
- The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults
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Jung-Hee Yu, Seo Hyoung Yim, Su Hyeon Yu, Ji Yong Lee, Jong Dae Kim, Mi Hae Seo, Won Seon Jeon, Se-Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
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Endocrinol Metab. 2013;28(1):33-40. Published online March 25, 2013
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DOI: https://doi.org/10.3803/EnM.2013.28.1.33
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- Background
We investigated the association of coronary artery calcium score (CACS) with body composition and insulin resistance in apparently healthy Korean adults. MethodsNine hundred forty-five participants (mean age, 48.9 years; 628 men) in a medical check-up program were selected for analysis. Body composition was assessed by bioelectrical impedance analysis (BIA). Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). The CACS was assessed by multidetector computed tomography. ResultsOne hundred forty-six subjects (15.4%) showed coronary artery calcification and 148 subjects (15.7%) had metabolic syndrome. CACS showed a significant positive correlation with age, fasting glucose level, waist circumference (WC), blood pressure, hemoglobin A1c, HOMA-IR, and waist-hip ratio (WHR) assessed by BIA. CACS had a negative correlation with high density lipoprotein cholesterol (HDL-C). Subjects with high CACS showed significantly higher mean WHRs and lower mean values for lean body mass compared with subjects without coronary artery calcification. In logistic regression analyses with coronary artery calcification as the dependent variable, the highest quartile of WHR showed a 3.125-fold increased odds ratio for coronary artery calcification compared with the lowest quartile after adjustment for confounding variables. When receiver operating characteristics analyses were performed with coronary artery calcification as the result variable, WHR showed the largest area under the curve (AUC) value among other variables except for age and WC in women (AUC=0.696 for WHR, 0.790 for age, and 0.719 for WC in women). ConclusionIn our study population of apparently healthy Korean adults, WHR was the most significant predictor for coronary artery calcification among other confounding factors, suggesting that it may have implication as a marker for early atherosclerosis.
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- Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
Göran Bergström, Annika Rosengren, Elin Bacsovics Brolin, John Brandberg, Kerstin Cederlund, Gunnar Engström, Jan E. Engvall, Maria J. Eriksson, Isabel Gonçalves, Emil Hagström, Stefan K. James, Tomas Jernberg, Mikael Lilja, Martin Magnusson, Anders Perss Atherosclerosis.2023; 373: 46. CrossRef - Association Between Measures of Body Composition and Coronary Calcium: Findings From the Multi‐Ethnic Study of Atherosclerosis
Tamara Horwich, Preethi Srikanthan, Anisha Gaitonde, Karol Watson, Matthew Allison, Richard Kronmal Journal of the American Heart Association.2023;[Epub] CrossRef - Pericardial fat, thoracic peri-aortic adipose tissue, and systemic inflammatory marker in nonalcoholic fatty liver and abdominal obesity phenotype
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Youngmi Eun, Su Nam Lee, Jin Jung, Min Sik Kim, Keon-Woong Moon, Ki-Dong Yoo Menopause.2020; 27(9): 1010. CrossRef - Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
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Teresa Padro, Natàlia Muñoz-García, Gemma Vilahur, Patricia Chagas, Alba Deyà, Rosa Antonijoan, Lina Badimon Nutrients.2018; 10(9): 1237. CrossRef - Effects of Low-density Lipoprotein Cholesterol on Coronary Artery Calcification Progression According to High-density Lipoprotein Cholesterol Levels
Da Young Lee, Ji Hyun Kim, Se Eun Park, Cheol-young Park, Ki-won Oh, Sung-woo Park, Eun-Jung Rhee, Won-young Lee Archives of Medical Research.2017; 48(3): 284. CrossRef - Decreased muscle mass in Korean subjects with intracranial arterial stenosis: The Kangbuk Samsung Health Study
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H.-S. Kim, H. Kim, H. Lee, B. Park, S. Park, S.-H. Lee, J. H. Cho, H. Song, J. H. Kim, K.-H. Yoon, I. Y. Choi Journal of Clinical Pharmacy and Therapeutics.2016; 41(1): 70. CrossRef - Increased risk for development of coronary artery calcification in insulin-resistant subjects who developed diabetes: 4-year longitudinal study
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Hyung-Geun Oh, Shriram Nallamshetty, Eun-Jung Rhee Diabetes & Metabolism Journal.2016; 40(1): 54. CrossRef - Characteristics of Body Composition and Muscle Strength of North Korean Refugees during South Korean Stay
Sun Wook Cho, So Hee Lee, Eun Sil Koh, Si Eun Kim, Seok Joong Kim Endocrinology and Metabolism.2015; 30(4): 551. CrossRef - Higher association of coronary artery calcification with non-alcoholic fatty liver disease than with abdominal obesity in middle-aged Korean men: the Kangbuk Samsung Health Study
Min-Kyung Lee, Hye-Jeong Park, Won Seon Jeon, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee Cardiovascular Diabetology.2015;[Epub] CrossRef - Increased Risk for Intracranial Arterial Stenosis in Subjects With Coronary Artery Calcification
Hyung-Geun Oh, Pil-Wook Chung, Eun-Jung Rhee Stroke.2015; 46(1): 151. CrossRef - Metabolic syndrome criteria as predictors of subclinical atherosclerosis based on the coronary calcium score
Mi Hae Seo, Eun-Jung Rhee, Se Eun Park, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won-Young Lee The Korean Journal of Internal Medicine.2015; 30(1): 73. CrossRef - Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: Comparing the two guidelines in a large Korean cohort
Eun-Jung Rhee, Se Eun Park, Hyung Geun Oh, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Ron Blankstein, Jorge Plutzky, Won-Young Lee Atherosclerosis.2015; 240(1): 242. CrossRef - Relationship of Glycated Hemoglobin A1c, Coronary Artery Calcification and Insulin Resistance in Males Without Diabetes
Chan-Hee Jung, Eun-Jung Rhee, Kyu-Jin Kim, Bo-Yeon Kim, Se Eun Park, Yoosoo Chang, Seungho Ryu, Cheol-Young Park, Ji-Oh Mok, Ki-Won Oh, Chul-Hee Kim, Sung-Woo Park, Sung-Koo Kang, Won-Young Lee Archives of Medical Research.2015; 46(1): 71. CrossRef - Metabolic Health Is a More Important Determinant for Diabetes Development than Simple Obesity: A 4-Year Retrospective Longitudinal Study
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- Obesity and Metabolism
- Tumor Necrosis Factor-α as a Predictor for the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Follow-Up Study
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Yun Yong Seo, Yong Kyun Cho, Ji-Cheol Bae, Mi Hae Seo, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
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Endocrinol Metab. 2013;28(1):41-45. Published online March 25, 2013
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DOI: https://doi.org/10.3803/EnM.2013.28.1.41
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- Background
Tumor necrosis factor (TNF)-α is associated with insulin resistance and systemic inflammatory responses. The aim of this study was to investigate the relationship between TNF-α and the development of nonalcoholic fatty liver disease (NAFLD) in a longitudinal study. MethodsThree hundred and sixty-three apparently healthy subjects (mean age, 40.5±6.1 years; male, 57.6%) without NAFLD were enrolled in 2003. Anthropometric and laboratory measurements were performed. The participants were grouped into tertiles according to their serum TNF-α levels from samples taken in 2003. At a 4-year follow-up, we compared the odds ratios (ORs) of the development of NAFLD according to the tertiles of TNF-α levels measured in 2003. ResultsAt the 4-year follow-up, the cumulative incidence of NAFLD was 29.2% (106/363). The group that developed NAFLD had higher levels of TNF-α than those in the group without NAFLD (3.65±1.79 pg/mL vs. 3.15±1.78 pg/mL; P=0.016). When the 2003 serum TNF-α levels were categorized into tertiles: incidence of NAFLD observed in 2007 was significantly higher with increasing tertiles (22.6%, 35.8%, and 41.5%, respectively; P<0.05). The risk of developing NAFLD was significantly greater in the highest tertile of TNF-α than in the lowest tertile after adjusting for age, smoking, and BMI (OR, 2.20; 95% confidence interval, 1.12 to 4.01; P<0.05). ConclusionHigher serum TNF-α levels in subjects without NAFLD were associated with the development of NAFLD. The results of study might suggest a pathologic role of inflammation in NAFLD.
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